DNA ligases seal 5′-PO4 and three′-OH polynucleotide finishes by means of three nucleotidyl transfer methods involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal structures of DNA ligases sure to nucleotide and nucleic acid substrates have https://beniton890uqh4.wikilinksnews.com/user