Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals in the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have identified recurrent mutations in genes regulating tumor mobile-microenvironment interactions, which... https://davek665crh2.vidublog.com/profile