There is a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to lower afferent discomfort transmission and make analgesia. Therefore, medicine like clonidine that focus on alpha-2 receptors can impact the transmission of pain. Clonidine is dispersed in breast milk; https://aristotlee378kdx2.nizarblog.com/profile