Butabarbital will lessen the level or impact of nifedipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown. butabarbital will lessen the extent or effect of aprepitant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. butabarbital will lessen the extent or influence of hydrocortisone by affecting hepatic/intestinal enz... https://pauli009rbm5.sunderwiki.com/user