Methylxanthines may additionally compete for benzodiazepine receptors in the CNS and inhibit phosphodiesterase, leading to elevated levels of cyclic adenosine monophosphate (cyclic AMP). Methylxanthines may also maximize circulating levels of epinephrine and norepinephrine. The oral LD50 in dogs of both of those caffeine and theobromine is reportedly 100–two hundred mg/kg, https://trevorscimr.targetblogs.com/37385718/the-5-second-trick-for-safe-chocolate-alternatives-for-dogs